Phosphodiesterase 6D cGMP-Specific Rod Delta Human Recombinant ( PDE6D Human )

PDE6D produced in E.Coli is a single, non-glycosylated polypeptide chain containing 158 amino acids (1-150 a.a.) and having a molecular mass of 18.4kDa. PDE6D is fused to an 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques.

Greater than 90.0% as determined by SDS-PAGE.

Human PDE6D was initially identified as a fourth subunit of rod-specific cGMP phosphodiesterase, PDE6. PDE6D is an Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. PDE6D interacts with RPGR, ARL2 and ARL3. The catalytically active PDE6 is a heterodimer (& #945; & #946; ) that is controlled by two inhibitory & #947; subunits. Since PDE6D does not change the catalytic properties of PDE& #945; & #946; , its function is still unanswered. PDE6D is expressed specifically in the retina.

Sterile filtered colorless solution.

Proteases