AKR1D1 cDNA

cDNA

Aldo-keto reductase family 1, member D1, also known as AKR1D1, is a member of the AKR superfamily. The AKR family of proteins are soluble NADPH oxidoreductases. They play important roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1D1 is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones which carry a delta (4) -3-one structure. AKR1D1 is highly expressed in liver, colon and testis. Deficiency of this enzyme may contribute to hepatic dysfunction.

Human

604741

981bp

1. Centrifuge at 7000rpm for 1 minute.; ; 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA.; ; Each tube contains approximately 10ug of lyophilized plasmid.

MDLSAASHRI PLSDGNSIPI IGLGTYSEPK STPKGACATS VKVAIDTGYR HIDGAYIYQN EHEVGEAIRE KIAEGKVRRE DIFYCGKLWA TNHVPEMVRP TLERTLRVLQ LDYVDLYIIE VPMAFKPGDE IYPRDENGKW LYHKSNLCAT WEAMEACKDA GLVKSLGVSN FNRRQLELIL NKPGLKHKPV SNQVECHPYF TQPKLLKFCQ QHDIVITAYS PLGTSRNPIW VNVSSPPLLK DALLNSLGKR YNKTAAQIVL RFNIQRGVVV IPKSFNLERI KENFQIFDFS LTEEEMKDIE ALNKNVRFVE LLMWRDHPEY PFHDEY

ATGGATCTCA GTGCTGCAAG TCACCGCATA CCTCTAAGTG ATGGAAACAG CATTCCCATC ATCGGACTTG GTACCTACTC AGAACCTAAA TCGACCCCTA AGGGAGCCTG TGCAACATCG GTGAAGGTTG CTATTGACAC AGGGTACCGA CATATTGATG GGGCCTACAT CTACCAAAAT GAACACGAAG TTGGGGAGGC CATCAGGGAG AAGATAGCAG AAGGAAAGGT GCGGAGGGAA GATATCTTCT ACTGTGGAAA GCTATGGGCT ACAAATCATG TCCCAGAGAT GGTCCGCCCA ACCCTGGAGA GGACACTCAG GGTCCTCCAG CTAGATTATG TGGATCTTTA CATCATTGAA GTACCCATGG CCTTTAAGCC AGGAGATGAA ATATACCCTA GAGATGAGAA TGGCAAATGG TTATATCACA AGTCAAATCT GTGTGCCACT TGGGAGGCGA TGGAAGCTTG CAAAGACGCT GGCTTGGTGA AATCCCTGGG AGTGTCCAAT TTTAACCGCA GGCAGCTGGA GCTCATCCTG AACAAGCCAG GACTCAAACA CAAGCCAGTC AGCAACCAGG TTGAGTGCCA TCCGTATTTC ACCCAGCCAA AACTCTTGAA ATTTTGCCAA CAACATGACA TTGTCATTAC TGCATATAGC CCTTTGGGGA CCAGTAGGAA TCCAATCTGG GTGAATGTTT CTTCTCCACC TTTGTTAAAG GATGCACTTC TAAACTCATT GGGGAAAAGG TACAATAAGA CAGCAGCTCA AATTGTTTTG CGTTTCAACA TCCAGCGAGG GGTGGTTGTC ATTCCTAAAA GCTTTAATCT TGAAAGGATC AAAGAAAATT TTCAGATCTT TGACTTTTCT CTCACTGAAG AAGAAATGAA GGACATTGAA GCCTTGAATA AAAATGTCCG CTTTGTAGAA TTGCTCATGT GGCGCGATCA TCCTGAATAC CCATTTCATG ATGAATACTG A