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BCL2A1 (A1) Antibody (BH3 Domain Specific) Blocking peptide

BCL2A1 (A1) Antibody (BH3 Domain Specific) Blocking peptide

Item no.	ABC-BP1300a
Manufacturer	Abcepta
Amount	500 ug
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	BCL2A1, BCL2L5, BFL1, GRS, HBPA1, Bcl-2-related protein A1, Bcl-2-like protein 5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS, Bcl2-L-5
Available
Primary Accession	Q16548
Bio Background	Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
Bio References	Akatsuka, Y., et al., J. Exp. Med. 197(11):1489-1500 (2003).Edelstein, L.C., et al., Mol. Cell. Biol. 23(8):2749-2761 (2003).Werner, A.B., et al., J. Biol. Chem. 277(25):22781-22788 (2002).Akari, H., et al., J. Exp. Med. 194(9):1299-1311 (2001).Harrington, J.J., et al., Nat. Biotechnol. 19(5):440-445 (2001).
Gene ID	597
Gene Name	BCL2A1
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence used to generate the antibody AP1300a was selected from the region of human A1 BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 10/2/2025

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