Bio Background |
The protein encoded by this gene is a member of the STATprotein family. In response to cytokines and growth factors, STATfamily members are phosphorylated by the receptor associatedkinases, and then form homo- or heterodimers that translocate tothe cell nucleus where they act as transcription activators. Inresponse to interferon (IFN), this protein forms a complex withSTAT1 and IFN regulatory factor family protein p48 (ISGF3G), inwhich this protein acts as a transactivator, but lacks the abilityto bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP)has been shown to interact specifically with this protein, which isthought to be involved in the process of blocking IFN-alpharesponse by adenovirus. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq]. |
Bio References |
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Lou, Y.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(3):255-258(2010)Rosas-Murrieta, N.H., et al. Virol. J. 7, 263 (2010) : |