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RIPK1 Antibody (N-term) Blocking peptide

RIPK1 Antibody (N-term) Blocking peptide

Item no.	ABC-BP13893a
Manufacturer	Abcepta
Amount	500 ug
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	RIPK1, RIP, RIP1, Receptor-interacting serine/threonine-protein kinase 1, Cell death protein RIP, Receptor-interacting protein 1, Serine/threonine-protein kinase RIP, RIP-1
Available
Primary Accession	Q13546
Bio Background	Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
Bio References	Kim, S., et al. Cancer Sci. 101(11):2425-2429(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Chae, Y.S., et al. J. Cancer Res. Clin. Oncol. (2010) In press :Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)Vandenabeele, P., et al. Sci Signal 3 (115), RE4 (2010) :
Gene ID	8737
Gene Name	RIPK1 (HGNC:10019)
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence used to generate the antibody AP13893a was selected from the N-term region of RIPK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 10/2/2025

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