Bio Background |
This gene encodes one of the receptors for serotonin, aneurotransmitter with many roles. Mutations in this gene areassociated with susceptibility to schizophrenia andobsessive-compulsive disorder, and are also associated withresponse to the antidepressant citalopram in patients with majordepressive disorder (MDD). MDD patients who also have a mutation inintron 2 of this gene show a significantly reduced response tocitalopram as this antidepressant downregulates expression of thisgene. Multiple transcript variants encoding different isoforms havebeen found for this gene. |
Bio References |
Blaya, C., et al. Neurosci. Lett. 485(1):11-15(2010)Klein, A.B., et al. J. Cereb. Blood Flow Metab. 30 (11), E1-E7 (2010) :Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401(4):605-610(2010)Terrazzino, S., et al. Headache (2010) In press :Kapelski, P., et al. Psychiatr. Pol. 44(2):197-206(2010) |