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EIF4E Blocking Peptide (N-term)

EIF4E Blocking Peptide (N-term)

Item no.	ABC-BP1954a
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology By Cell Type Hematology Leukemia Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Rychlik,W., J. Biol. Chem. 262 (22), 10434-10437 (1987) Dorfman,J., Genomics 9 (4), 785-788 (1991) Pelletier,J., Genomics 10 (4), 1079-1082 (1991) Whalen,S.G., J. Biol. Chem. 271 (20), 11831-11837 (1996)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Eukaryotic translation initiation factor 4E,eIF-4E,eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein,EIF4E,EIF4EL1,EIF4F
Similar products	EIF4E, EIF4EL1, EIF4F, Eukaryotic translation initiation factor 4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, eIF4E, eIF-4E
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence is selected from aa 47-61 of HUMAN EIF4E
Bio Background	eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. this gene also interacts mutually exclusive with EIF4A1 and EIF4A2.
Gene Name	EIF4E
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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