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CDKN1A Blocking Peptide (C-term)

CDKN1A Blocking Peptide (C-term)

Item no.	ABC-BP20643c
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Peptides & Proteins Cell Biology Cell Status Apoptosis Senescence Peptides By Organ Lung Cancer
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Harper J.W.,et al.Cell 75:805-816(1993). El-Deiry W.S.,et al.Cell 75:817-825(1993). Xiong Y.,et al.Nature 366:701-704(1993). Jiang H.,et al.Mol. Cell. Differ. 1:285-299(1993). Jiang H.,et al.Oncogene 10:1855-1864(1995).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Cyclin-dependent kinase inhibitor 1,CDK-interacting protein 1,Melanoma differentiation-associated protein 6,MDA-6,p21,CDKN1A,CAP20,CDKN1,CIP1,MDA6,PIC1,SDI1,WAF1
Similar products	p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence is selected from aa 133-144 of HUMAN CDKN1A
Bio Background	May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Gene Name	CDKN1A
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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