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(Mouse) Trim24 Blocking Peptide (C-term)

(Mouse) Trim24 Blocking Peptide (C-term)

Item no.	ABC-BP20896c
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology By Cell Type Carcinoma Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	le Douarin B.,et al.EMBO J. 14:2020-2033(1995). le Douarin B.,et al.EMBO J. 15:6701-6715(1996). Zhong S.,et al.Nat. Genet. 23:287-295(1999). Seeler J.-S.,et al.Mol. Cell. Biol. 21:3314-3324(2001). Torres-Padilla M.E.,et al.J. Cell Biol. 174:329-338(2006).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Transcription intermediary factor 1-alpha,TIF1-alpha,632-,E3 ubiquitin-protein ligase Trim24,Tripartite motif-containing protein 24,Trim24,Tif1,Tif1a
Similar products	Transcription intermediary factor 1-alpha, Tripartite motif-containing protein 24, E3 ubiquitin-protein ligase Trim24, 632-, TIF1-alpha, Trim24, Tif1, Tif1a
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence is selected from aa 789-823 of HUMAN Trim24
Bio Background	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.
Gene Name	Trim24
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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