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SMURF2 Antibody (N-term) Blocking Peptide

SMURF2 Antibody (N-term) Blocking Peptide

Item no.	ABC-BP2105a
Manufacturer	Abcepta
Amount	500 ug
Category	Peptides & Proteins Cell Biology Cell Status Senescence Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Zhang, Y., et al., Proc. Natl. Acad. Sci. U.S.A. 98(3):974-979 (2001).Kavsak, P., et al., Mol. Cell 6(6):1365-1375 (2000).Lin, X., et al., J. Biol. Chem. 275(47):36818-36822 (2000).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	E3 ubiquitin-protein ligase SMURF2,hSMURF2,632-,SMAD ubiquitination regulatory factor 2,SMAD-specific E3 ubiquitin-protein ligase 2,SMURF2
Similar products	SMURF2, E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, hSMURF2, 632-
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP2105a was selected from the N-term region of human SMURF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83% identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. The nuclear SMURF2/phosphorylated SMAD2 interaction is requires TGFB1.
Gene Name	SMURF2
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-BP2105a-datasheet.pdf

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Amount: 500 ug

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Delivery expected until 1/1/2026

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