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(Mouse) Smad3 Blocking Peptide (Center)

(Mouse) Smad3 Blocking Peptide (Center)

Item no.	ABC-BP21216c
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology Peptides & Proteins Peptides By Organ Colorectal Cancer
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Kano K.,et al.J. Vet. Med. Sci. 61:213-219(1999). Yang X.,et al.Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases. Carninci P.,et al.Science 309:1559-1563(2005). Liu X.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:10669-10674(1997). Ashcroft G.S.,et al.Nat. Cell Biol. 1:260-266(1999).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Mothers against decapentaplegic homolog 3,MAD homolog 3,Mad3,Mothers against DPP homolog 3,mMad3,SMAD family member 3,SMAD 3,Smad3,Smad3,Madh3
Similar products	Smad3, Mothers against decapentaplegic homolog 3, SMAD family member 3, Mad3, SMAD 3, Mothers against DPP homolog 3, MAD homolog 3, Madh3, mMad3
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence is selected from aa 188-202 of HUMAN Smad3
Bio Background	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Gene Name	Smad3
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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