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Mouse Runx1 Blocking Peptide (C-term)

Mouse Runx1 Blocking Peptide (C-term)

Item no.	ABC-BP21256b
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Development By Cell Type Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Bae S.-C.,et al.Oncogene 8:809-814(1993). Bae S.-C.,et al.Mol. Cell. Biol. 14:3242-3252(1994). Calabi F.,et al.Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. Tsuji K.,et al.Biochem. Biophys. Res. Commun. 274:171-176(2000). Fujita Y.,et al.Biochem. Biophys. Res. Commun. 281:1248-1255(2001).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Runt-related transcription factor 1,Acute myeloid leukemia 1 protein,Core-binding factor subunit alpha-2,CBF-alpha-2,Oncogene AML-1,Polyomavirus enhancer-binding protein 2 alpha B subunit,PEA2-alpha B,PEBP2-alpha B,SL3-3 enhancer factor 1 alpha B subunit,SL3/AKV core-binding factor alpha B subunit,Runx1,Aml1,Cbfa2,Pebp2ab
Similar products	Runx1, Acute myeloid leukemia 1 protein, Runt-related transcription factor 1, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, Aml1, Cbfa2, Pebp2ab
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence is selected from aa 305-319 of HUMAN Runx1
Bio Background	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B- dependent transcriptional activation (By similarity).
Gene Name	Runx1
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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