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(Mouse) Ehmt2 Blocking Peptide (Center)

Item no. ABC-BP21305c
Manufacturer Abcepta
Amount 500 ug
Category
Type Peptides
Format Lyophilized
Specific against other
Citations Tachibana M.,et al.Genes Dev. 16:1779-1791(2002).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Brown S.E.,et al.Mamm. Genome 12:916-924(2001).
Tachibana M.,et al.J. Biol. Chem. 276:25309-25317(2001).
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Histone-lysine N-methyltransferase EHMT2,211-,Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Protein G9a,Ehmt2,Bat8,G9a,Ng36
Similar products H3-K9-HMTase 3, Bat8, Euchromatic histone-lysine N-methyltransferase 2, G9a, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, Histone-lysine N-methyltransferase EHMT2, 211-, Ehmt2, Protein G9a, Ng36
Available
Manufacturer - Category
Peptides; Blocking Peptides
Manufacturer - Targets
The synthetic peptide sequence is selected from aa 589-603 of HUMAN Ehmt2
Bio Background
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys- 373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Gene Name
Ehmt2
Subtitle
Synthetic peptide
Formulation
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

ABC-BP21305c-datasheet.pdf

Amount: 500 ug
Available: In stock
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