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Mouse Epas1 Blocking Peptide (C-term)

Mouse Epas1 Blocking Peptide (C-term)

Item no.	ABC-BP21549b
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology By Cell Type Carcinoma Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Tian H.,et al.Genes Dev. 11:72-82(1997). Ema M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:4273-4278(1997). Flamme I.,et al.Mech. Dev. 63:51-60(1997). Lando D.,et al.Genes Dev. 16:1466-1471(2002). Gradin K.,et al.J. Biol. Chem. 277:23508-23514(2002).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Endothelial PAS domain-containing protein 1,EPAS-1,HIF-1-alpha-like factor,HLF,mHLF,HIF-related factor,HRF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Epas1,Hif2a
Similar products	HLF, Endothelial PAS domain-containing protein 1, HIF-1-alpha-like factor, Hypoxia-inducible factor 2-alpha, EPAS-1, Epas1, Hif2a, HRF, mHLF, HIF-related factor, HIF-2-alpha, HIF2-alpha
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence is selected from aa 713-727 of HUMAN Epas1
Bio Background	Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
Gene Name	Epas1
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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