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SQSTM1 (p62) Antibody (C-term) Blocking peptide

SQSTM1 (p62) Antibody (C-term) Blocking peptide

Item no.	ABC-BP2183b
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology Neuroscience Protein Aggregation, Clearance & Misfolding By Cell Type Carcinoma Peptides & Proteins Cell Biology Cell Status Adenocarcinoma Autophagy Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Seibenhener, M.L., et al., Mol. Cell. Biol. 24(18):8055-8068 (2004).Eekhoff, E.W., et al., Arthritis Rheum. 50(5):1650-1654 (2004).Brajenovic, M., et al., J. Biol. Chem. 279(13):12804-12811 (2004).Kuusisto, E., et al., J. Neuropathol. Exp. Neurol. 62(12):1241-1253 (2003).Johnson-Pais, T.L., et al., J. Bone Miner. Res. 18(10):1748-1753 (2003).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Sequestosome-1,EBI3-associated protein of 60 kDa,EBIAP,p60,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,Ubiquitin-binding protein p62,SQSTM1,ORCA,OSIL
Similar products	SQSTM1, p60, ORCA, OSIL, Sequestosome-1, EBI3-associated protein of 60 kDa, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBIAP
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP2183b was selected from the C-term region of human SQSTM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.
Gene Name	SQSTM1 {ECO:0000303\|PubMed:16286508, ECO:0000312\|HGNC:HGNC:11280}
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 1/1/2026

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