MARCKS-like 1 Protein (MLP) Antibody (N-term) Blocking peptide

Protein kinase C is a key enzyme of intracellular signal transduction. The myristoylated, alanine-rich protein MARCKS, is a widely expressed, prominent substrate for protein kinase C.The severe neural tube defects (NTD) including exencephaly, spina bifida, and tail flexion anomaly in approximately 60% of the homozygous mutants and in approximately 10% of heterozygous animals. The homozygous mutants without exencephaly survived despite brain abnormalities, which appear to occur secondarily to the NTD.It has been suggested that mutations in Mrp result in isolated NTD and therefore may provide an animal model for common human NTD.

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Synthetic peptide

The synthetic peptide sequence used to generate the antibody AP2522a was selected from the N-term region of human MLP . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.