Comparison

INPP5D Antibody (Center) Blocking Peptide

Item no. ABC-BP2845c
Manufacturer Abcepta
Amount 500 ug
Category
Type Peptides
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products SHIP1, INPP5D, Phosphatidylinositol 3, SHIP-1, 5-trisphosphate 5-phosphatase 1, hp51CN, Inositol polyphosphate-5-phosphatase of 145 kDa, p150Ship, SH2 domain-containing inositol phosphatase 1, SIP-145, SHIP, SH2 domain-containing inositol 5'-phosphatase 1
Available
Primary Accession
Q92835
Bio Background
INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3, 4, 5)-trisphosphate and inositol-1, 3, 4, 5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.
Bio References
Gilby, D.C., Leukemia 21 (11), 2390-2393 (2007)Gloire, G., Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)Vaillancourt, M., Cell. Signal. 18 (11), 2022-2032 (2006)
Gene ID
3635
Gene Name
INPP5D
Subtitle
Synthetic peptide
Target/Specificity
The synthetic peptide sequence used to generate the antibody AP2845c was selected from the Center region of human INPP5D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 ug
Available: In stock
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