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Phospho-SMAD3(S208) Antibody Blocking peptide

Phospho-SMAD3(S208) Antibody Blocking peptide

Item no.	ABC-BP3249a
Manufacturer	Abcepta
Amount	500 ug
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	SMAD3, Smad3, MADH3, Mothers against decapentaplegic homolog 3, JV15-2, SMAD family member 3, Mad3, SMAD 3, Mothers against DPP homolog 3, hSMAD3, hMAD-3, MAD homolog 3
Available
Primary Accession	P84022
Bio Background	SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 80% of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMAD translocate into nucleus, where they regulate transcription of target genes. SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperresponsiveness observed in scleroderma.
Bio References	Imoto, S., et al., FEBS Lett. 579(13):2853-2862 (2005).Dubrovska, A., et al., Oncogene 24(14):2289-2297 (2005).Furumatsu, T., et al., J. Biol. Chem. 280(9):8343-8350 (2005).Kobayashi, T., et al., Biochem. Biophys. Res. Commun. 327(2):393-398 (2005).Kamaraju, A.K., et al., J. Biol. Chem. 280(2):1024-1036 (2005).
Gene ID	4088
Gene Name	SMAD3
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence used to generate the antibody AP3249a was selected from the region of human Phospho-SMAD3-S208. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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