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Phospho-TSC2(S1420) Antibody Blocking peptide

Phospho-TSC2(S1420) Antibody Blocking peptide

Item no.	ABC-BP3480a
Manufacturer	Abcepta
Amount	500 ug
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	TSC2, TSC4, Tuberin, Tuberous sclerosis 2 protein
Available
Primary Accession	P49815
Bio Background	Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Bio References	Li, Y., et al., Mol. Cell. Biol. 24(18):7965-7975 (2004).Karbowniczek, M., et al., J. Biol. Chem. 279(29):29930-29937 (2004).Corradetti, M.N., et al., Genes Dev. 18(13):1533-1538 (2004).Birchenall-Roberts, M.C., et al., J. Biol. Chem. 279(24):25605-25613 (2004).Lewis, J.C., et al., J. Med. Genet. 41(3):203-207 (2004).
Gene ID	7249
Gene Name	TSC2
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence used to generate the antibody AP3480a was selected from the region of human Phospho-TSC2-S1420. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 9/4/2025

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