Phospho-ALK(Y1282) Blocking Peptide

Peptides; Blocking Peptides

The 2; 5 chromosomal translocation is frequently associatedwith anaplastic large cell lymphomas (ALCLs). The translocationcreates a fusion gene consisting of the ALK (anaplastic lymphomakinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM fromchromosome 5. A recent study shows that the product of the NPM-ALKfusion gene is oncogenic. The deduced amino acid sequences revealthat ALK is a novel receptor protein-tyrosine kinase having aputative transmembrane domain and an extracellular domain. Thesesequences are absent in the product of the transforming NPM-ALKgene. ALK shows the greatest sequence similarity to LTK (leukocytetyrosine kinase). ALK plays an important role in the development ofthe brain and exerts its effects on specific neurons in the nervoussystem.

Synthetic peptide