Phospho-EP300(S1834) Blocking Peptide

Peptides; Blocking Peptides

This gene encodes the adenovirus E1A-associated cellularp300 transcriptional co-activator protein. It functions as histoneacetyltransferase that regulates transcription via chromatinremodeling and is important in the processes of cell proliferationand differentiation. It mediates cAMP-gene regulation by bindingspecifically to phosphorylated CREB protein. This gene has alsobeen identified as a co-activator of HIF1A (hypoxia-induciblefactor 1 alpha), and thus plays a role in the stimulation ofhypoxia-induced genes such as VEGF. Defects in this gene are acause of Rubinstein-Taybi syndrome and may also play a role inepithelial cancer.

Synthetic peptide