Comparison

Afadin (MLLT4) Antibody (Center A1152) Blocking peptide

Item no. ABC-BP6191d
Manufacturer Abcepta
Amount 500 ug
Category
Type Peptides
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products MLLT4, Afadin, AF6, ALL1-fused gene from chromosome 6 protein, Protein AF-6
Available
Primary Accession
P55196
Bio Background
Most acute leukemias in infancy and at least 5% of acute lymphoblastic leukemias and acute myeloid leukemias of older children and adults show abnormalities of chromosome band 11q23. In these cases, translocation results in fusion of a gene at 11q23, variously called ALL1, MLL, and the human homolog of Drosophila trithorax, with part of a gene on chromosome 4, chromosome 9, or chromosome 19. The cloning and characterization of the partner gene involved in a fourth common translocation involving 11q23, t(6; 11)(q27; q23) has been described. The gene, designated MLLT4 or alternatively AF6, expressed in a variety of cell types and encoded a protein of 1, 612 amino acids. The protein contains short stretches rich in proline, charged amino acids, serines, or glutamines. In addition, the AF6 protein contains the GLGF motif shared with several proteins of vertebrates and invertebrates thought to be involved in signal transduction at special cell-cell junctions. Using rapid amplification of cDNA ends (RACE) by PCR, the breakpoint in AF6 was confirmed and a cDNA clone that was used as a probe to screen a chromosome 6 cosmid library was identified. By fluorescence in situ hybridization, the single clone that was isolated was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to that region.
Bio References
1. Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004). 2. Mungall, A.J., et al., Nature 425(6960):805-811 (2003). 3. Saito, S., et al., DNA Res. 5(2):115-120 (1998). 4. Prasad, R., et al., Cancer Res. 53(23):5624-5628 (1993). 5. Takai, Y., et al., J. Cell. Sci. 116 (PT 1), 17-27 (2003).
Gene ID
4301
Gene Name
AFDN (HGNC:7137)
Subtitle
Synthetic peptide
Other Accession
Q5TIG7
Target/Specificity
The synthetic peptide sequence used to generate the antibody AP6191d was selected from the Center region of human MLLT4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 ug
Available: In stock
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