MMP23 Antibody (N-term) Blocking Peptide

Peptides; Blocking Peptides

Matrix Metalloproteases (MMPs) are zinc-dependent endopeptidases that break down the extracellular matrix, and thus play important roles in many physiological processes including embryonic development, wound healing, reproduction, tissue remodeling, arthritis, cancer and cardiovascular disease. Although most MMPs are secreted, the membrane-type MMPs (MT-MMPs) are anchored to the cell membrane by a transmembrane and intracytoplasmic domain. MMP activities are regulated at several levels, including cleavage of proenzyme forms and suppression via tissue inhibitors of metalloproteinases (TIMPs). Matrix Metalloproteinase 23, first identified in tumor cells, features a number of unqie properties among the MMPs: 1) cysteine array unique among the MMPs, 2) sublocalized expression of MMP23 to reproductive organs, 3) a furin cleavage site, 4) and is the sole MMP mapped to chromosome 1.

Synthetic peptide