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SMAD3 Antibody (Center D201) Blocking Peptide

SMAD3 Antibody (Center D201) Blocking Peptide

Item no.	ABC-BP6267a
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology Peptides & Proteins Peptides By Organ Colorectal Cancer
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Imoto, S., et al., FEBS Lett. 579(13):2853-2862 (2005).Dubrovska, A., et al., Oncogene 24(14):2289-2297 (2005).Furumatsu, T., et al., J. Biol. Chem. 280(9):8343-8350 (2005).Kobayashi, T., et al., Biochem. Biophys. Res. Commun. 327(2):393-398 (2005).Kamaraju, A.K., et al., J. Biol. Chem. 280(2):1024-1036 (2005).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Mothers against decapentaplegic homolog 3,MAD homolog 3,Mad3,Mothers against DPP homolog 3,hMAD-3,JV15-2,SMAD family member 3,SMAD 3,Smad3,hSMAD3,SMAD3,MADH3
Similar products	SMAD3, Smad3, MADH3, Mothers against decapentaplegic homolog 3, JV15-2, SMAD family member 3, Mad3, SMAD 3, Mothers against DPP homolog 3, hSMAD3, hMAD-3, MAD homolog 3
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP6267a was selected from the Center region of human SMAD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 80% of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMADS translocate into the nucleus, where they regulate transcription of target genes. The SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperresponsiveness observed in scleroderma.
Gene Name	SMAD3
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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