« Back
Home /
ADRBK1 Antibody (C-term) Blocking peptide

ADRBK1 Antibody (C-term) Blocking peptide

Item no.	ABC-BP7004a
Manufacturer	Abcepta
Amount	500 ug
Category	Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Cardiovascular Research Heart Failure Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Li, J., et al., J. Biol. Chem. 278(32):30219-30226 (2003).Wan, K.F., et al., J. Biol. Chem. 278(20):18658-18663 (2003).Yang, X.L., et al., World J. Gastroenterol. 9(4):800-803 (2003).Hagen, S.A., et al., Anesthesiology 98(2):343-348 (2003).Eichmann, T., et al., J. Biol. Chem. 278(10):8052-8057 (2003).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Beta-adrenergic receptor kinase 1,Beta-ARK-1,G-protein coupled receptor kinase 2,ADRBK1,BARK,BARK1,GRK2
Similar products	Beta-ARK-1, ADRBK1, GRK2, BARK1, G-protein coupled receptor kinase 2, BARK, Beta-adrenergic receptor kinase 1
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP7004a was selected from the C-term region of human GRK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	Beta-adrenergic receptor kinase (ADRBK1), also known as GRK2, phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Gene Name	GRK2
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ABC-BP7004a-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 500 ug

available

Delivery expected until 11/6/2025

Express Delivery: Save 14 days

Compare

Add to wishlist

Get an offer