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MNK1 Antibody (N-term) Blocking Peptide

MNK1 Antibody (N-term) Blocking Peptide

Item no.	ABC-BP7154a
Manufacturer	Abcepta
Amount	500 ug
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	MKNK1, MNK1, MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase signal-integrating kinase 1, Mnk1, MAPK signal-integrating kinase 1
Available
Primary Accession	Q9BUB5
Bio Background	MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence.C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also binds strongly to the stress-activated kinase, p38.
Bio References	Orton, K.C., et al., J. Biol. Chem. 279(37):38649-38657 (2004).Cuesta, R., et al., J. Virol. 78(14):7707-7716 (2004).Knauf, U., et al., Mol. Cell. Biol. 21(16):5500-5511 (2001).Cuesta, R., et al., Genes Dev. 14(12):1460-1470 (2000).Fukunaga, R., et al., EMBO J. 16(8):1921-1933 (1997).
Gene ID	8569
Gene Name	MKNK1
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence used to generate the antibody AP7154a was selected from the N-term region of human MNK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 10/2/2025

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