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CDK4 Antibody (C-term) Blocking Peptide

CDK4 Antibody (C-term) Blocking Peptide

Item no.	ABC-BP7520b
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Mori, N., et al., Int. J. Hematol. 77(3):259-262 (2003).Masaki, T., et al., Hepatology 37(3):534-543 (2003).Gump, J., et al., J. Biol. Chem. 278(9):6619-6622 (2003).Ramirez, R.D., et al., Oncogene 22(3):433-444 (2003).Detjen, K.M., et al., Exp. Cell Res. 282(2):78-89 (2003).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Cyclin-dependent kinase 4,Cell division protein kinase 4,PSK-J3,CDK4
Similar products	CDK4, Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP7520b was selected from the C-term region of human CDK4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.
Gene Name	CDK4
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-BP7520b-datasheet.pdf

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Amount: 500 ug

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Delivery expected until 11/6/2025

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