TBK1 Antibody (S172) Blocking peptide

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

29110

Synthetic peptide

The synthetic peptide sequence used to generate the antibody AP7887a was selected from the S172 region of human TBK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.