Bio Background |
WEE1 is a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. |
Bio References |
Kawasaki, H., et al., Oncogene 22(44):6839-6844 (2003).Hashimoto, O., et al., Mol. Carcinog. 36(4):171-182 (2003).Yuan, H., et al., J. Virol. 77(3):2063-2070 (2003).Masaki, T., et al., Hepatology 37(3):534-543 (2003).de Noronha, C.M., et al., Science 294(5544):1105-1108 (2001). |