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Calcineurin (PPP3CA) Antibody (C-term) Blocking peptide

Calcineurin (PPP3CA) Antibody (C-term) Blocking peptide

Item no.	ABC-BP8463b
Manufacturer	Abcepta
Amount	500 ug
Category	Neuroscience Neural Signaling Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Yoshizaki, T., et al., J. Biol. Chem. 279(21):22715-22726 (2004).Flajolet, M., et al., Proc. Natl. Acad. Sci. U.S.A. 100(26):16006-16011 (2003).Ofek, P., et al., J. Biol. Chem. 278(16):14299-14305 (2003).Matsuda, A., et al., Oncogene 22(21):3307-3318 (2003).Cheng, A., et al., Genes Dev. 13(22):2946-2957 (1999).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform,CAM-PRP catalytic subunit,Calmodulin-dependent calcineurin A subunit alpha isoform,PPP3CA,CALNA,CNA
Similar products	PPP3CA, CAM-PRP catalytic subunit, CALNA, CNA, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, Calmodulin-dependent calcineurin A subunit alpha isoform
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP8463b was selected from the C-term region of human PPP3CA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	PPP3CA is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis.
Gene Name	PPP3CA
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-BP8463b-datasheet.pdf

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Amount: 500 ug

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Delivery expected until 11/6/2025

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