LOXL2, Recombinant, Human, His-Tag (Lysyl Oxidase-like Protein 2, Lysyl Oxidase Related Protein 2, LOR2, Lysyl Oxidase Homolog 2, Lysyl Oxidase Related Protein WS9-14)

Dry Ice

85

Supplied as a liquid in 8mM PBS, pH 7.4, 110mM sodium chloride, 2.2mM potassium chloride, 200mM imidazole, 20% glycerol.

Lysyl Oxidase Homolog 2 (lysyl oxidase-like protein 2, LOXL2) is a member of lysyl oxidase-like (LOXL) gene family which includes LOXL1 through LOXL4. These enzymes are secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. The N-terminal region of LOXL2 contains four scavenger receptor cysteine- rich (SRCR) domains, and the C-terminal region is a catalytic domain similar to other lysyl oxidases. The catalytic domain contains conserved residues required for copper binding and formation of a lysyl tyrosylquinone co-factor. Although some of the LOXL enzymes are known to cross-link collagen and elastin substrates, such a function has yet to be characterized for LOXL2. It has been shown that LOXL2 promotes cell migration and tumor cell invasiveness. Elevated expression of LOXL2 is also associated with cancer progression in various tumors and carcinoma cell lines, which makes it a potential marker for prognosis of cancer. LOXL2 is expressed in many tissues, with elevated levels in reproductive tissues such as placenta, uterus, and prostate.

Source:
Recombinant corresponding to aa26-774 from human LOXL2, fused to His-tag at C-terminal, expressed in FreeStyle 293-F cells.

Molecular Weight:
~85kD

Applications:
Specific methodologies for the use of this product have not been tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.