a1-Antitrypsin, Recombinant, Mouse, aa25-413, His-Tag (Serpin A1a, Aat2, Dom1, PI1, Spi1-1)

Blue Ice

5060

Supplied as a liquid in Tris, NaCl.

Serpin A1a, also known as alpha-1-antitrypsin, belongs to the serpin superfamily of proteinase inhibitors. It is one of five alpha 1-proteinase inhibitors produced in mice. Serpin A1a is produced in the liver, then secreted into the bloodstream. It inhibits a number of serine proteases, including elastase, trypsin, plasmin, and thrombin (1, 2). Serpin A1a’s major function is to protect the lungs from neutrophil elastase. Serpin A1a deficiency can cause complications such as emphysema, and chronic obstructive pulmonary disease (COPD).

Source:
Recombinant protein corresponding to Glu25-Lys413 from mouse Serpin A1a, fused to 6-his tag at C-terminal, NS0-derived.

Molecular Weight:
~50-60kD

Endotoxin:
<1.0EU/1ug (LAL method).

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.