Natriuretic Peptide Receptor B, aa288-302, Human (NPR-B)

Molecular Biology / MB-Receptors

-20°C

Supplied as a lyophilized powder. No preservatives added. Reconstitute with 0.1% acetic acid.

Synthetic peptide (QNRLLIRAREDFGVE) corresponding to aa 288-302 of human NPR-B

ANPB (natriuretic peptide receptor B) is one of two integral membrane receptors for natriuretic peptides. Both ANPA and ANPB contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain), an helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. ANPB is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity.

Synthetic peptide (QNRLLIRAREDFGVE) corresponding to aa288-302 of human NPR-B

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with 0.1% acetic acid. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.