Recombinant Human Interleukin-4 , Yeast

IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Pichia pastoris.

The protein was lyophilized from0.2um filtered solution in 20mM sodium phosphate buffer pH 6.0 in absence of any carrier protein.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Lyophilized Interleukin-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Interleukin-4 should be stored at 4C between 2-7 days and for future use below -18C.
Please prevent freeze-thaw cycles.