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Recombinant Human Dipeptidyl-Peptidase 4

Recombinant Human Dipeptidyl-Peptidase 4

Item no.	enz-375-10ug
Manufacturer	ProSpec
Amount	10ug
Category	Metabolism Diabetes Peptides & Proteins Enzymes
Type	Enzymes
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160410
ECLASS 11.0	32160410
UNSPSC	12352204
Similar products	DPP4
Available
Synonyms	CD26, ADABP, ADCP2, DPPIV, TP103, DPP4, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2, CD26 antigen
Introduction	DPP4 also called adenosine deaminase complexing protein-2, and T-cell activation antigen CD26 is a serine exopeptidase and complex enzyme that is expressed on the surface of most cell types. DPPIV is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. DPP4 plays a role in t-cell activation. DPP4 is associated with intracellular signal transduction, apoptosis and involved in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).
Description	DPPIV Human Recombinant produced in High-5 cells is a single, glycosylated polypeptide chain containing 746 amino acids (39-766) and having a molecular mass of 86.4 kDa. DPPIV is fused to His Tag at C-terminus and purified using conventional chromatography techniques.
Source	High-5 cells.
Physical Appearance	Sterile Filtered colorless solution.
Formulation	DPP4 is formulated in 20mM Tris-HCl buffer pH-8, 100mM NaCl, 1mM EDTA and 10% glycerol.
Purity	Greater than 95.0% as determined by Analysis by SDS-PAGE. On SDS-PAGE under denatured condition, apparent molecular weight of glycosylated DPP4 will migrate at approximately 90kDa.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Amino acid sequence	ADP-SRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENN ILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQ FILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIP NNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRIT WTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFL AYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAG AVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGD HYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESS GRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSF YKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIE ALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCL SCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTL HSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIIL NETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKAD TVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHA INRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWS YGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYT ERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIH GTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHG IASSTAHQHIYTHMSHFIKQCFSLP-SGRLVPRGSHHHHHH.
Biological Activity	20 Units/mg.
Storage	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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enz-375-10ug-safety-datasheet.pdf