« Back
Home /
Recombinant Human Fibrinogen Silencer Binding Protein

Recombinant Human Fibrinogen Silencer Binding Protein

Item no.	pro-1493-10ug
Manufacturer	ProSpec
Amount	10ug
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Synonyms	Fibrinogen silencer-binding protein, FSBP
Introduction	Fibrinogen silencer-binding protein (FSBP), interacts with X11alpha. The X11alpha/FSBP complex send signals to the nucleus in order to repress glycogen synthase kinase-3beta promoter activity. X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) via a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's diseased brains.
Description	FSBP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 322 amino acids (1-299 a.a.) and having a molecular mass of 37.2kDa. FSBP is fused to a 23 amino acid His-tag at N-terminus purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered clear solution.
Formulation	FSBP protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 1M Urea and 10% glycerol.
Purity	Greater than 85.0% as determined by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Amino acid sequence	MGSSHHHHHH SSGLVPRGSH MGS MVGKARS SNFTLSEKLD LLKLVKPYVK ILEEHTNKHS VIVEKNRCWD IIAVNYNAIG VDRPPRTAQG LRTLYKRLKE YAKQELLQQK ETQSDFKSNI SEPTKKVMEM IPQISSFCLV RDRNHIQSAN LDEEAQAGTS SLQVMLDHHP VAITVEVKQE EDIKPPPPLV LNSQQSDTLE QREEHELVHV MERSLSPSLS SVDMRMTSSP SSIPRRDDFF RHESGEHFRS LLGYDPQILQ MLKEEHQIIL ENQKNFGLYV QEKRDGLKRR QQLEEELLRA KIEVEKLKAI RLRHDLPEYN SL.
Storage	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

pro-1493-10ug-safety-datasheet.pdf