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Recombinant Human Transmembrane Emp24-Like Trafficking Protein 10

Recombinant Human Transmembrane Emp24-Like Trafficking Protein 10

Item no.	pro-1636-0.1mg
Manufacturer	ProSpec
Amount	0.1mg
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Synonyms	Transmembrane Emp24-Like Trafficking Protein 10 (Yeast), Transmembrane Emp24 Domain-Containing Protein 10, 21 KDa Transmembrane Trafficking Protein, P24 Family Protein Delta-1, p24delta1, Transmembrane Protein Tmp21, S31III125, TMP21, Tmp-21-I, p23
Introduction	TMED10, which has a GOLD domain, belongs to the EMP24/GP25L/p24 family. TMED10, a type I membrane protein is restricted to the plasma membrane and golgi cisternae and takes part in vesicular protein transferring. Additionally, TMED10 is a fragment of the heteromeric secretase complex and controls the complex's gamma- secretase activity without influencing its epsilon-secretase activity. Alterations in TMED10 are linked to early-onset familial Alzheimer's disease. TMED10 has a pseudogene on chromosome 8.
Description	TMED10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (32-185) and having a molecular mass of 20.0kDa. TMED10 is fused to a 23 amino acid His-tag at N-terminus purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile filtered colorless solution.
Formulation	The TMED10 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 30% glycerol.
Purity	Greater than 85% as determined by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Amino acid sequence	MGSSHHHHHH SSGLVPRGSH MGS ISFHLPI NSRKCLREEI HKDLLVTGAY EISDQSGGAG GLRSHLKITD SAGHILYSKE DATKGKFAFT TEDYDMFEVC FESKGTGRIP DQLVILDMKH GVEAKNYEEI AKVEKLKPLE VELRRLEDLS ESIVNDFAYM KKREEEMRDT NESTNTR
Storage	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1mg

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Delivery expected until 9/18/2025

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