Recombinant Mouse Fibroblast Growth Factor-acidic

Acidic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.

Escherichia Coli.

Lyophilized at a concentration of 1 mg/ml in 5mM NaP, pH-7.5, 50mM NaCl.

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The ED50 as determined by the dose-dependent proliferation of mouse BALB/c 3T3 cells, is less than 0.2 ng/ml corresponding to a Specific Activity of 5, 000, 000IU/mg.