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Cathepsin S

Cathepsin S

Item no.	ARP-12-7626
Manufacturer	American Research Products
Amount	25 ug
Category	Peptides & Proteins Native Proteins
Type	Proteins Native
Specific against	other
Purity	> 90% by SDS-PAGE
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Description	Like cathepsin B, H, and L, cathepsin S belongs to the group of lysosomal cysteine proteinases. Cathepsin S is found primarily in the spleen and in lung macrophages. Its level is elevated in the brain tissue of those with Alzheimer's disease and Down syndrome. Cathepsin S may function in the processing of amyloid precursor protein to amyloid beta peptides.
Form	Purified, lyophilized from 100 mM Na-Acetate, 1 mM EDTA, pH 5.5
Storage	2-8C for immediate use, or at -20C (aliquot)
Purity	>, 90% by SDS-PAGE
Source	Human spleen. Nonreactive and negative for HBsAg, anti-HCV, anti-HBc, and anti-HIV by FDA-required tests
Molecular Weight	24, 000 Daltons
Biological Activity	183.8 mU/mg (before freezing), using method described by Kirsche &, Wiederlanders in Method in Enzymology, 244: 500-511 (1994) One unit is defined as the amount of Cathepsin S which will hydrolyze Z-Val-Arg-NHMec in an assay buffer of 0.1M KPO4, 5mM disodium EDTA, pH 6.5, at 25AC, for 5 minutes, giving a change in fluorescence of 40, 000 fluorescence units. The assay is standardized so that a 0.1 M solution of free 7-amino-4-methylcoumarin gives a reading of 1000 fluorescence units

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 ug

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Delivery expected until 12/18/2025

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