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Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN) (Active)

Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN) (Active)

Item no.	BM-RPC26518-1mg
Manufacturer	Biomatik
Amount	1mg
Category	Neuroscience Neural Lineage Markers Peptides & Proteins Recombinant Proteins Glial Cell Markers
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-36Ra, IL-1-related protein 3, IL-1RP3, Interleukin-1 HY1, IL-1HY1
Similar products	IL-1-related protein 3, Interleukin-1 HY1, IL-1RP3, IL-36Ra, IL-1HY1
Available
Gene Name	IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, UNQ1896/PRO4342
Alternative Names	IL-36Ra, IL-1-related protein 3, IL-1RP3, Interleukin-1 HY1, IL-1HY1
Uniprot	Q9UBH0
Source	E.coli
Expression Region	2-155aa
AA Sequence	VLSGALCFRM KDSALKVLYL HNNQLLAGGL HA GKVIKGEE ISVVPNRWLD ASLSPVILGV QGGS QCLSCG VGQEPTLTLE PVNIMELYLG AKESKS FTFY RRDMGLTSSF ESAAYPGWFL CTVPEADQ PV RLTQLPENGG WNAPITDFYF QQCD
Sequence Info	Full Length of Mature Protein
Tag Info	Tag-Free
Theoretical MW	16.8 kDa
Purity	>95% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.4
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by inhibiting IL-36 beta induced IL-8 secretion by human preadipocytes is less than 1.0 ug/ml, corresponding to a specific activity of ? 1000 IU/mg in the presence of 20 ng/ml of recombinant human IL-36 beta.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269\|PubMed:11466363, ECO:0000269\|PubMed:21965679, ECO:0000269\|PubMed:23147407}.
Function	Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Involvement in disease	Psoriasis 14, pustular (PSORS14)
Subcellular location	Secreted
Protein Families	IL-1 family
Tissue Specificity	Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1mg

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Delivery expected until 12/11/2025

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