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Recombinant Human C-C motif chemokine 14 protein (CCL14) (Active)

Recombinant Human C-C motif chemokine 14 protein (CCL14) (Active)

Item no.	BM-RPC26559-100ug
Manufacturer	Biomatik
Amount	100ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Chemokine CC-1/CC-3, HCC-11-74 NCC-2, Small-inducible cytokine A14
Similar products	Chemokine CC-1/CC-3, Small-inducible cytokine A14, HCC-11-74 NCC-2
Available
Gene Name	CCL14, NCC2, SCYA14
Alternative Names	Chemokine CC-1/CC-3, HCC-11-74 NCC-2, Small-inducible cytokine A14
Uniprot	Q16627
Source	E.coli
Expression Region	22-93aa
AA Sequence	TESSSRGPYH PSECCFTYTT YKIPRQRIMD YY ETNSQCSK PGIVFITKRG HSVCTNPSDK WVQD YIKDMK EN
Sequence Info	Partial
Tag Info	Tag-Free
Theoretical MW	8.4 kDa
Purity	>96% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.4
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 5.0-20 ng/ml.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1, 000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. {ECO:0000269\|PubMed:11085751}.
Function	Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1, 000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Subcellular location	Secreted
Protein Families	Intercrine beta (chemokine CC) family
Tissue Specificity	Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
Paythway	Chemokinesignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 9/11/2025

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