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Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein (TNFRSF11A) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein (TNFRSF11A) (Active)

Item no.	BM-RPC26714-100ug
Manufacturer	Biomatik
Amount	100 UG
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Aging & Neurological Disorders By Cell Type Carcinoma Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis By Organ Lymphatic System Cancer
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Osteoclast differentiation factor receptor, Receptor activator of NF-KB, CD antigen CD265
Similar products	Osteoclast differentiation factor receptor, Receptor activator of NF-KB, CD antigen CD265
Available
Gene Name	TNFRSF11A, RANK
Alternative Names	Osteoclast differentiation factor receptor, Receptor activator of NF-KB, CD antigen CD265
Uniprot	Q9Y6Q6
Source	E.coli
Expression Region	29-202aa
AA Sequence	QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KC TTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVC DTGKAL VAVVAGNSTT PRRCACTAGY HWSQDC ECCR RNTECAPGLG AQHPLQLNKD TVCKPCLA GY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK
Sequence Info	Partial
Tag Info	Tag-Free
Theoretical MW	19.1 kDa
Purity	>98% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered 20 mM Tris-HCl, pH 8.0, 150mM NaCl
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of ? 2.0 x 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269\|PubMed:9878548}.
Function	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Involvement in disease	Familial expansile osteolysis (FEO); Paget disease of bone 2, early-onset (PDB2); Osteopetrosis, autosomal recessive 7 (OPTB7)
Subcellular location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform RANK-e5a: Cell membrane, Single-pass type I membrane protein
Tissue Specificity	Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
Paythway	NF-kappaBsignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 UG

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Delivery expected until 2/12/2026

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