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Recombinant Human Neuroserpin protein (SERPINI1) (Active)

Recombinant Human Neuroserpin protein (SERPINI1) (Active)

Item no.	BM-RPC26745-100ug
Manufacturer	Biomatik
Amount	100ug
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience By Cell Type Blastoma Carcinoma Hematology Lymphoma Sarcoma Peptides & Proteins Recombinant Proteins Glial Cell Markers
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Peptidase inhibitor 12, Serpin I1
Similar products	Peptidase inhibitor 12, Serpin I1
Available
Gene Name	SERPINI1, PI12
Alternative Names	Peptidase inhibitor 12, Serpin I1
Uniprot	Q99574
Source	E.coli
Expression Region	17-406aa
AA Sequence	TGATFPEEAI ADLSVNMYNR LRATGEDENI LF SPLSIALA MGMMELGAQG STQKEIRHSM GYDS LKNGEE FSFLKEFSNM VTAKESQYVM KIANSL FVQN GFHVNEEFLQ MMKKYFNAAV NHVDFSQN VA VANYINKWVE NNTNNLVKDL VSPRDFDAAT YLALINAVYF KGNWKSQFRP ENTRTFSFTK D DESEVQIPM MYQQGEFYYG EFSDGSNEAG GIY QVLEIPY EGDEISMMLV LSRQEVPLAT LEPLV KAQLV EEWANSVKKQ KVEVYLPRFT VEQEIDL KDV LKALGITEIF IKDANLTGLS DNKEIFLSK A IHKSFLEVNE EGSEAAAVSG MIAISRMAVL YPQVIVDHPF FFLIRNRRTG TILFMGRVMH PE TMNTSGHD
Sequence Info	Partial
Tag Info	Tag-Free
Theoretical MW	44.7 kDa
Purity	>95% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.5
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.5 ug/ml, corresponding to a specific activity of > 2000 IU/mg.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
Function	Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin
Involvement in disease	Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB)
Subcellular location	Secreted, Cytoplasmic vesicle, secretory vesicle lumen, Perikaryon
Protein Families	Serpin family
Tissue Specificity	Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Predominantly expressed in the brain (PubMed:9070919).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 12/11/2025

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