Recombinant Human Brain-derived neurotrophic factor (BDNF) (Active)

BDNF

P23560

129-247aa

Full Length of Mature Protein

13 kDa

Lyophilized from a 0.2 um filtered 20 mM PB, 250 mM NaCl, pH 7.2

The ED50 as determined by its ability to bind Human TrkB in functional ELISA is less than 5 ug/ml.

Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.

For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Secreted

Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.