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Human Claudin-18.1 Protein, His,Twin-Strep Tag (Detergent)

Human Claudin-18.1 Protein, His,Twin-Strep Tag (Detergent)

Item no.	CL1-H5588-20ug
Manufacturer	ACROBiosystems
Amount	20 ug
Quantity options	100 ug 20 ug 500 ug
Category	Peptides & Proteins Amino Acids
Type	Proteins
Format	Liquid
Specific against	Human (Homo sapiens)
Host	Insect Cells
Conjugate/Tag	Unconjugated, Twin-Strep, HIS
Dry ice	Yes
NCBI	NP_057453.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Claudin-18.1,CLDN18,Claudin-18
Shipping condition	Dry ice
Available
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	N-10×His & C-Twin-Strep, Unconjugated
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	26.5 kDa
Description	Human Claudin-18.1, His, Twin-Strep Tag (CL1-H5588) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-1).
Background	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Molecule	Claudin-18.1
Exp Region	Met 1 - Ala 200
Characteristics	This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus. The protein has a calculated MW of 26.5 kDa.
Buffer	50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Stability	The product MUST be stored at -70°C or lower upon receipt; -70°C for 6 months under sterile conditions.
Protectant	glycerol

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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CL1-H5588-20ug-safety-datasheet.pdf