Recombinant SARS-CoV-2 (2019-nCoV) Spike S1 RBD Protein(His Tag)

Stable for up to 1 year from date of receipt at -20°C to -80°C. It is recommended to store working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors that bind S1 are ACE2, angiotensinconverting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, Oacetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARSCoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.