PDGF-R Beta-(His)C, ECD, Human, Recombinant

dry ice

Oncology

Platelet derived growth factor Receptor (PDGF-R) is a tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGF? and PDGF? and for heterodimers formed by PDGF? and PDGF?, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of mesangial cells in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGF?, heterodimers formed by PDGF? and PDGF? or homodimeric PDGF? -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGF-R? and PDGF-R?. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.