« Back
Home /
Recombinant Human GDNF Protein, His Tag

Recombinant Human GDNF Protein, His Tag

Item no.	KMD-KMH1156-50ug
Manufacturer	KMD Bioscience
Amount	50 ug
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	His
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ATF, ATF1, ATF2, HSCR3, HFB1-GDNF, glial cell derived neurotrophic factor
Available
Molecular Name	GDNF
Source	This protein contains the human GDNF(Ser78-Ile211) was fused with the C-terminal His Tag and expressed in E. coli.
Uniprot Accession	P39905
Purity	>=90% as determined by SDS-PAGE
Endotoxin	Please contact our customer service for more information.
Buffer	PBS
Purification	Protein A/G
Predicted Molecular Weight	14.74kDa
Background	GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR alpha(alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 11) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Storage	Store the product under sterile conditions after opening at -20C to -80C for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 ug

available

Delivery expected until 9/18/2025

Express Delivery: Save 27 days

Compare

Add to wishlist

Get an offer