Recombinant Human Stratifin/SFN Protein, No Tag

SFN

P31947

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Protein A/G

14-3-3sigma or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents. The induction of 14-3-3sigma is mediated by a p53 responsive element. Exogenous introduction of 14-3-3sigma into cycling cells results in a G2 cell cycle arrest. Knockout of 14-3-3sigma in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3sigma -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3sigma -deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3sigma plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death.

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