Recombinant Human TIMP-2 Protein, His Tag

TIMP2

P16035

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

The tissue Inhibitor of Metalloproteinases (TIMP) belongs to a family which takes part in the activation and regulation of the MMP-activity: TIMP-1, a 28-kDa glycoprotein; TIMP-2, a 21-kDa glycoprotein and the N-glycosylated TIMP-3 (27-kDa, reduced SDS-PAGE). TIMP-4 is thought to function in a tissue-specific fashion in the ECM hemostasis. These proteins are expressed in a variety of cell types and form with latent as well as with active MMPs non-covalent, stoichiometric complexes. Progelatinase B and the activated gelatinase B specifically bind TIMP-1 via their C-terminal domain. Purified TIMP-2 inhibits the activities of stromelysin 1 (MMP-3), matrilysin (MMP-7), gelatinase A (MMP-2) and the interstitial collagenase (MMP-1).On the MMP-2 the TIMP displays two distinct binding sites.

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